Shaping mucosal and systemic immunity by non-digestible oligosaccharides and postbiotics

Ayechu Muruzabal, Veronica

Promoter:
Prof.dr J. (Johan) Garssen
Co-promoter:
Dr L.E.M. (Linette) Willemsen & dr B. (Belinda) van 't Land
Research group:
Garssen
Date:
December 12, 2022
Time:
14:15 h

Summary

Upon birth the gastro-intestinal tract and the immune system of the newborn need to develop to adapt to the extra-uterine environment and to protect the newborn against infections and allergy. Nutrition is a key factor directly influencing the maturation and development of the gastrointestinal tract and the immune system. The ability of non-digestible oligosaccharides, human milk oligosaccharides and postbiotics in promoting the maturation and development of the intestinal epithelial and innate as well as adaptive immune cells was studied in order to develop possible strategies to support mucosal immune maturation.