Free amino acids in human milk

A potential role in early life growth and immunity

Sadelhoff, Joris van

Promoter:
Prof.dr J. (Johan) Garssen & dr F.A.M. (Frank) Redegeld
Co-promoter:
Dr A. (Astrid) Hogenkamp & dr S.P. (Selma) Wiertsema
Research group:
Garssen
Date:
March 30, 2022
Time:
10:15 h

Summary

Breastfeeding is the gold standard for infant nutrition. It promotes healthy growth, supports immune system development and provides the infant with components that could help in the protection against infections and allergies. Given the relevance of early life growth and immunity for health throughout life, there is great interest in identifying and understanding the components in human milk that could contribute to these physiological effects of breastfeeding.

One group of components in human milk that could be of relevance in this context, but has been only scarcely studied, are free amino acids (FAAs). In this thesis, we demonstrated that concentrations of FAAs in human milk change as the infant ages, indicating a need for an adequate FAA intake in early life. We further found that concentrations of certain FAAs positively correlated with infant growth in the first months of life. Moreover, dietary supplementation with the FAA glutamine, which is abundant in human milk, was found to inhibit the development of food-allergic symptoms in mice. These findings support the hypothesis that FAAs could contribute to the unique growth- and immune-related benefits associated with breastfeeding, which calls for further research into the functions of FAAs in early life development. Understanding these functions is important considering our observation that FAA concentrations in human milk may be influenced by maternal characteristics, such as body mass index and allergy status. Moreover, understanding these functions could provide opportunities for optimizing human milk substitutes, which generally contain lower concentrations of FAAs than human milk.