The mechanisms of urticaria and angioedema

Mehran Alizadeh Aghdam

Chronic Urticaria (CSU) is a common skin disease characterized by intensely pruritic wheals, development of angioedema (AE), or both. Treatment consists of antihistamines, with the addition of omalizumab in refractory cases. The underlying pathophysiology of CSU is not fully delineated, but activation of cutaneous mast cells is thought to play a key role. In this project we investigate among others the involvement of other leukocytes and the complement system. Furthermore we investigate the use of omalizumab and its optimal treatment regiment in CU.