Modification of allergenic proteins with glycans for oral tolerance induction

The objective of this program is to investigate whether modification of allergenic milk and peanut proteins or peptides thereof with glycans that are known to induce tolerogenic responses, can support oral tolerance induction by altering the antigen-specific T-cell response from a Th2-dominant response towards a more tolerogenic response (Treg) and diminish IgE-mediated responses by inhibiting IgE class switching and/or interfering with IgE-mediated responses.

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Juliët Schaapherder