Human genetic determinants of invasive group A streptococcal host-pathogen interactions
The molecular basis of human specificity in group A streptoccocal host-pathogen interactions and clinical variability upon pathogen exposure and subsequent (invasive) infection remain unknown. We aim to elucidate the human genetic determinants of invasive group A streptococcal host-pathogen interactions that may predispose to and underlie severe and potentially fatal invasive infections in ostensibly healthy individuals.
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Gabriël Schut