Dynamic (phospho)proteome and metabolome analysis in coronavirus infected cells

During this project, we will perform comparative metabolomics & (phospho)proteomics analysis of coronavirus infected cells/cultures to identify (drugable) pathways that are commonly affected upon infection with coronaviruses. At first, these analyses will be performed on infected cells (cell lines) to obtain an overview of what pathways are targeted by coronaviruses. Afterwards, we will make use of more biologicaly and clinically relevant systems, such as human airway epithelial cell cultures, to validate and interfere with these pathways.

Lonneke Nouwen