Control of MRSA in the pig nasal microbiome to prevent transmission to humans

Using metagenomics and state of the art bioinformatics we will identify commensal bacteria that are negatively associated with Staphylococcus aureus in the pig nose. The interaction of these commensal species with Staphyloccus aureus will be studied in detail in order to define and produce a cocktail of commensal bacteria that will protect the pig nose from colonization with MRSA. Proof of concept will be shown using ex vivo tissue cultures, in vivo animal models, and finally in a comprehensive field trial.