Complement resistance mechanisms by multi-drug resistant Klebsiella pneumonia

The aim of this project is to characterize complement evasion molecules in the opportunistic bacterium Klebsiella pneumoniae.

This project has two main objectives:

  1. Identify Klebsiella proteins (either secreted or expressed in the outer membrane) that interfere with complement activation.
  2. Decipher how complement-resistant Klebsiella strains withstand direct killing by the complement system.

Frerich Masson