Causes and consequences of clonal haematpoiesis in pediatric haematopoietic stem cell transplantation survivors

Clinical duties concerning the clinical study about clonal hematopoiesis (CH) in long term pediatric HSCT survivors. Determine the incidence and risk factors for CH in pediatric HSCT survivors. Investigate long term chimerism in the above mentioned study population. Write literature review about reversible features of stem cell ageing. Investigate relationship between haematopoietic stem cell ageing (by looking into inflammation, immunity and epigenetic) and CH in pediatric HSCT survivors. Setting up a second clinical study where we will prospectively follow pediatric HSCT survivors and among others monitor CH, inflammation and immunity (and/or immune reconstitution) over time.

Nienke Wieringa